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. 2019 Sep 16;129(10):4492–4505. doi: 10.1172/JCI128212

Figure 5. DNPC can convert to a squamous phenotype.

Figure 5

(A) H&E staining of mCRPC tissues from LuCaP 173.2 and patient 13-084. Black arrows point to squamous pearl structures. (B) Expression of squamous cell lung cancer associated genes from RNA-Seq of LuCaP 173.2 DNPC cells and squamous pearl (SP) cells isolated by laser capture microdissection. Results are expressed as log2 FPKM and colored according to scale. (C) IHC of specimens from LuCaP 173.2 and patient 13-084 using KRT6 antibody or IgG as a negative control. (D) H&E staining (left panels) and KRT6 IHC (right panels) of DNPC tumor sections from patients 11-028 and 13-099. Scale bars: 20 μM.