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. 2019 Sep 9;129(10):4419–4432. doi: 10.1172/JCI129143

Figure 4. Ptpn18D197A mutant mice show reduced body weight, improved insulin sensitivity, and reduced insulin secretion from pancreatic islets.

Figure 4

Plasma glucose (A) and insulin (C) during an oGTT in female (n = 12, 13) and male (n = 19, 22) Ptpn18-WT and Ptpn18D197A mice, respectively, that were maintained on the HF/HS diet for 4 months; area under the curve (AUC) values for glucose (B) and insulin (D). Body weight at 18 weeks of age in female (n = 12, 13) and male (n = 19, 22) Ptpn18-WT and Ptpn18D197A mice, respectively (E). Number of islets harvested per mouse (F) (n = 8, 12) and insulin secretion (G) (n = 13, 16; G indicates glucose) from male Ptpn18-WT and Ptpn18D197A mice, respectively. *P < 0.05; **P < 0.01 for Student’s 2-tailed t test.