Fig. 4.
Human Ang-(1–12) Cleavage Sites of CPA and rhChymase. CPA sequentially cleaves the C-terminal end amino acids (Ile, Val, Leu, His and Phe) of hAng-(1–12). Chymase is an endopeptidase that cleaves one Phe8-His9 bond of the hAng-(1–12) substrate.