Table 3.
HRQOL by Type of Endocrine/Metabolic Disorder Among Adult Survivors of Childhood Cancers
| SF-36 Scale or Component Summary Score | Endocrine Disorder (Reference Group Is Survivors With No Endocrine Disorder) [RR (95% CI)] | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Any Thyroid Disorder | Any Growth Disorders | Gonadal Dysfunction (Males): Testicular Failure | Gonadal Dysfunction (Females): Ovarian Failure | Osteoporosis | Diabetes | Overweight/Obesity | Other Endocrine Disorders Not Specified | Any Endocrine Disorder | |
| Physical function | 1.03 (0.92–1.15) | 1.14 (0.99–1.32) | 1.52 (1.10–2.10) | 1.44 (1.18–1.76) | 1.29 (1.12–1.50) | 1.37 (1.04–1.79) | 1.20 (1.04–1.38) | 1.57 (1.19–2.06) | 1.25 (1.05–1.48) |
| Role physical | 1.25 (1.10–1.43) | 0.96 (0.82–1.14) | 1.13 (0.67–1.92) | 1.06 (0.84–1.36) | 1.41 (1.20–1.65) | 1.28 (1.09–1.50) | 1.00 (0.89–1.13) | 1.37 (1.00–1.87) | 1.09 (0.95–1.27) |
| Bodily pain | 1.00 (0.88–1.14) | 0.79 (0.68–0.93) | 1.58 (1.20–2.09) | 1.31 (1.06–1.62) | 1.37 (1.18–1.61) | 1.36 (1.09–1.70) | 1.28 (1.15–1.42) | 0.99 (0.71–1.38) | 1.27 (1.12–1.44) |
| General health | 1.27 (1.15–1.40) | 0.98 (0.87–1.11) | 1.17 (0.80–1.71) | 1.50 (1.32–1.70) | 1.45 (1.30–1.61) | 1.50 (1.30–1.72) | 1.26 (1.15–1.39) | 1.14 (0.91–1.43) | 1.49 (1.32–1.68) |
| Vitality | 1.21 (1.09–1.35) | 0.95 (0.83–1.08) | 1.59 (1.13–2.25) | 1.13 (0.94–1.36) | 1.20 (1.04–1.39) | 1.46 (1.28–1.68) | 1.19 (1.08–1.30) | 1.40 (1.15–1.71) | 1.21 (1.09–1.34) |
| Role emotional | 1.21 (1.06–1.38) | 0.89 (0.77–1.04) | 1.57 (1.07–2.30) | 1.06 (0.83–1.34) | 1.25 (1.04–1.49) | 0.93 (0.66–1.32) | 1.03 (0.92–1.15) | 1.04 (0.75–1.44) | 1.03 (0.91–1.17) |
| Social function | 1.13 (0.97–1.32) | 0.84 (0.70–0.99) | 1.63 (1.21–2.20) | 1.48 (1.17–1.87) | 1.19 (0.96–1.47) | 1.47 (1.12–1.92) | 1.03 (0.90–1.17) | 1.07 (0.75–1.52) | 1.07 (0.92–1.24) |
| Mental health | 1.04 (0.90–1.19) | 0.87 (0.75–1.02) | 1.44 (1.08–1.91) | 1.24 (0.99–1.56) | 1.28 (1.06–1.54) | 1.19 (0.88–1.60) | 1.05 (0.94–1.17) | 1.09 (0.80–1.47) | 1.09 (0.96–1.24) |
| Physical component summary | 1.09 (0.95–1.24) | 0.99 (0.83–1.18) | 1.01 (0.55–1.85) | 1.26 (1.08–1.46) | 1.45 (1.29–1.63) | 1.23 (1.08–1.40) | 1.25 (1.12–1.38) | 1.51 (1.15–1.99) | 1.30 (1.11–1.52) |
| Mental component summary | 1.16 (1.01–1.34) | 0.76 (0.64–0.90) | 1.67 (1.25–2.24) | 1.04 (0.80–1.34) | 1.03 (0.83–1.29) | 0.99 (0.70–1.41) | 0.99 (0.88–1.10) | 1.07 (0.77–1.50) | 0.98 (0.87–1.11) |
Adjusted for sex, race, education, marital status, household income, health insurance, employment status, radiation (yes/no), amputation, and other grade 3 to 4 chronic conditions.
Bold type indicates significant results.