Skip to main content
. Author manuscript; available in PMC: 2019 Sep 26.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2017 Apr 21;52(4):395–413. doi: 10.1080/10409238.2017.1314444

Figure 4:

Figure 4:

Rad51-independent BIR. A. A model of Rad51-independent BIR in yeast mediated by Rad52, Rad59, Rdh54 and the MRX complex in the absence of Rad51 where the 3’ end of a one-ended broken chromosome anneals to regions of transient ssDNA formed as a result of secondary DNA structures, R-loops, or stalled/collapsed replication forks. Annealing to ssDNA likely occurs at positions of microhomology. B. Model of Rad51-independent BIR to explain alternative lengthening of telomeres in human cells (similar to Type II-ALT events in yeast). ALT is initiated by annealing of resected uncapped telomere end to ssDNA in telomeric C-circles (as described in (Cesare and Reddel, 2010, Dilley and Greenberg, 2015)). A color version of the figure is available online.