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. Author manuscript; available in PMC: 2019 Sep 26.
Published in final edited form as: J Neurooncol. 2014 Jan;116(2):373–379. doi: 10.1007/s11060-013-1304-2

Fig. 1.

Fig. 1

a Task-based fMRI data consists of rapid echoplanar (EPI) acquisition over time during a stimulus. b To isolate the pseudo-resting state fMRI signal, the fMRI stimulus block design (gray dashed line) is first convolved with a hemodynamic response function and then deconvolved with the fMRI time-series data in each image voxel (black). c The residual signal after deconvolution is used to as pseudo-resting state fMRI data. From this pseudo-resting state fMRI data, voxels in each region of interest identified as part of the default mode network nodes are averaged to get a single fMRI time-series for each node. The functional connectivity between the average pseudo-resting state fMRI time series in each node is then calculated using a Pearson’s correlation coefficient, r. d Recognized nodes within the DMN include the ACC, PCC, LLPC, and RLPC