Table 3.
Emotional outcomes across racial/ethnic groups of childhood cancer survivors.
| White, non-Hispanic | Black, non-Hispanic | Hispanic | ||||||
|---|---|---|---|---|---|---|---|---|
| Mean | P | Mean | P | P* | Mean | P | P* | |
| Depression | ||||||||
| Sibling | 47.25 | 47.21 | 46.02 | |||||
| Survivor | 48.33 | 48.70 | 49.61 | |||||
| Survivor-sibling difference | 1.09 | <0.001 | 1.49 | 0.23 | 0.75 | 3.59 | <0.001 | 0.004 |
| Survivor no CRT | 48.16 | 48.47 | 49.55 | |||||
| Survivor-sibling difference | 0.91 | <0.001 | 1.26 | 0.33 | 0.79 | 3.52 | <0.001 | 0.004 |
| Survivor with CRT | 48.82 | 49.30 | 49.81 | |||||
| Survivor-sibling difference | 1.57 | <0.001 | 2.09 | 0.23 | 0.77 | 3.78 | 0.003 | 0.09 |
| Anxiety | ||||||||
| Sibling | 46.77 | 44.54 | 46.16 | |||||
| Survivor | 46.86 | 45.41 | 47.80 | |||||
| Survivor-sibling difference | 0.09 | 0.68 | 0.87 | 0.47 | 0.52 | 1.64 | 0.10 | 0.13 |
| Survivor no CRT | 47.06 | 45.73 | 47.83 | |||||
| Survivor-sibling difference | 0.29 | 0.19 | 1.19 | 0.35 | 0.48 | 1.67 | 0.11 | 0.19 |
| Survivor with CRT | 46.30 | 44.58 | 47.70 | |||||
| Survivor-sibling difference | −0.47 | 0.11 | 0.04 | 0.98 | 0.71 | 1.54 | 0.25 | 0.14 |
| Somatization | ||||||||
| Sibling | 48.11 | 47.68 | 48.92 | |||||
| Survivor | 49.14 | 50.67 | 50.35 | |||||
| Survivor-sibling difference | 1.03 | <0.001 | 3.00 | 0.01 | 0.11 | 1.43 | 0.12 | 0.67 |
| Survivor no CRT | 49.11 | 50.37 | 50.16 | |||||
| Survivor-sibling difference | 1.00 | <0.001 | 2.70 | 0.03 | 0.18 | 1.24 | 0.19 | 0.80 |
| Survivor with CRT | 49.23 | 51.44 | 50.95 | |||||
| Survivor-sibling difference | 1.12 | <0.001 | 3.76 | 0.02 | 0.11 | 2.03 | 0.10 | 0.47 |
| Global severity index | ||||||||
| Sibling | 46.74 | 45.08 | 46.11 | |||||
| Survivor | 47.52 | 47.60 | 48.95 | |||||
| Survivor-sibling difference | 0.78 | <0.001 | 2.52 | 0.08 | 0.23 | 2.85 | 0.005 | 0.05 |
| Survivor no CRT | 47.48 | 47.40 | 48.87 | |||||
| Survivor-sibling difference | 0.74 | 0.002 | 2.33 | 0.12 | 0.30 | 2.76 | 0.009 | 0.06 |
| Survivor with CRT | 47.64 | 48.10 | 49.23 | |||||
| Survivor-sibling difference | 0.90 | 0.005 | 3.02 | 0.10 | 0.25 | 3.12 | 0.04 | 0.14 |
P=p-value comparing survivors to same race/ethnicity siblings; P*=p-value comparing survivor-sibling difference between racial/ethnic groups, referenced to non-Hispanic white survivor-sibling difference.
Adjusted for sex, age at follow-up, year at diagnosis, methotrexate exposure (intravenous and intrathecal), corticosteroid exposure and any CTCAE grade 3-4 chronic medical condition.