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. Author manuscript; available in PMC: 2019 Dec 7.
Published in final edited form as: Mod Pathol. 2019 Jun 7;32(10):1434–1446. doi: 10.1038/s41379-019-0287-8

Figure 2.

Figure 2

H3K27me3 and H3K27me2 immunohistochemical staining of malignant peripheral nerve sheath tumors. (a) Three representative malignant peripheral nerve sheath tumors showing retained H3K27me3 nuclear staining also show strong staining for H3K27me2. (b) Similarly, malignant peripheral nerve sheath tumors with loss of H3K27me3 staining within tumor cells, show loss of H3K27me2. The sole case scored as H3K27me3-/H3K27me2+ showed only weak nuclear staining, less intense than infiltrating inflammatory cells (arrows, high-power inset, lower right).