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H&E (left) and H3K27me3 (middle) and H3K27me2 (right) immunohistochemical staining for representative cases of tumors characterized by loss of H3K27me3. (a) Malignant peripheral nerve sheath tumor (b) K27M glioma (c) PF-A Ependymoma (d) Merkel cell carcinoma. Of these tumors, only malignant peripheral nerve sheath tumor exhibits loss of nuclear H3K27me2 staining within tumor cells.
