Table 2.

SNP-based ($h_{SNP}^2$)and pedigree-based ($h^2$) heritability estimates for glycemic biomarkers^†

	$h^2$(SOLAR)		$h_{SNP}^2$(LDAK‡)		$h_{SNP}^2$(GCTA)
	Heritability (SE)	P-value	Heritability (SD)	P-value	Heritability (SE)	P-value
Fructosamine	0.44 (0.13)	2.9E–04	0.13 (0.06)	0.01	0.11 (0.03)	1.1E–03
Glycated albumin	0.45 (0.13)	1.8E–04	0.30 (0.07)	8.6E–07	0.10 (0.04)	2.5E–03
1,5–AG	0.55 (0.13)	1.3E–05	0.17 (0.06)	3.6E–03	0.15 (0.04)	5.3E–05
HbA1c	0.34 (0.13)	0.01	0.30 (0.07)	2.6E–06	0.17 (0.04)	1.1E–06
Fasting glucose	0.02 (0.03)	0.43	0.08 (0.07)	0.11	0.05 (0.04)	0.08

^†LDAK N=5,575, relatedness cutoff=0.25; GCTA N=6443, relatedness cutoff=0.05; SOLAR N=400

^‡LDAK inflation <3.3% for all heritability estimates