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. Author manuscript; available in PMC: 2020 Sep 25.
Published in final edited form as: Neuron. 2019 Aug 28;103(6):1044–1055.e7. doi: 10.1016/j.neuron.2019.07.026

Figure 3. The Adrb1-A187V mutation alters sleep/wake related behaviors in the FNSS mouse model.

Figure 3.

(A-C) Total mobile time by ANY-maze within 24 hours (A), dark phase (B) and light phase (C) were calculated in Adrb1 +/+ (N=20) and +/m (N=19) mice.

(D-F) Total sleep time by EEG/EMG within 24 hours (D), dark phase (E) and light phase (F) were calculated in Adrb1 +/+ (N=9) and +/m (N=13) mice.

(G-I) Total NREM sleep time within 24 hours (G), dark phase (H) and light phase (I) were calculated in Adrb1 +/+ (N=9) and +/m (N=13) mice.

(J-L) Total REM sleep time during a 24 hour day (J), dark phase (K) and light phase (L) were calculated in Adrb1 +/+ (N=9) and +/m (N=13) mice.

(M) Time course of EEG delta power (1.0–4.0 Hz) during NREM sleep across the light phase for Adrb1 +/+ (N=9) and +/m (N=9) mice.

* P<0.05, **P<0.01, *** P<0.001, **** P<0.0001, n.s.=not significant. Two-tailed Student’s t-test for (A)-(L).

Two way RM ANOVA, post-hoc Sidak’s multiple comparisons test for (M). Error bars represent ± SEM.

See Figures S1 for NREM and REM sleep bouts and duration calculation.