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. 2019 Sep 26;10(10):713. doi: 10.1038/s41419-019-1952-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Tamoxifen-induced Isl1 DNA recombine and decreased ISL1 protein level. Insufficient ISL1 protein bind to the Shh gene promoter lead to failure of Shh transcription activation. This affects commitment of urethral epithelial cell and increasing apoptosis then resulting in hypoplasia. The green line indicates positive regulation and the red line indicates negative regulation