Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 26;9:13931. doi: 10.1038/s41598-019-50329-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Bystander signaling is hampered through inhibition of NOX1. The presence of the NOX1 inhibitor AEBSF during CAP or PAM treatment prevents the generation of secondary ¹O₂. Therefore, only few cells will carry the “imprinted signature” of primary ¹O₂ action, i. e. a partially inactivated catalase population on their surface. To transmit bystander effect induction from this cell population to untreated cells requires to apply a much higher percentage of pretreated cells as under conditions without AEBSF. For this reason, the curves in the bystander experiments in this study show a strong right-ward shift in the presence of AEBSF during pretreatment and the kinetic analysis is characterized by a delay in apoptosis induction.