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. 2019 Sep 26;10(10):712. doi: 10.1038/s41419-019-1968-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a 5HD inhibits ROS levels in UM0112176 treated KLN205 cells. b 5HD does not protect against UM0112176-induced actin cytoskeleton (green) disruption. c Diminished caspase 3 (green) activation in cells pretreated with 5HD before UM0112176 incubation. d, e Ca²⁺ influx from external sources after UM0112176 stimulation of KLN205 and hNSCLC cells, respectively. f, g The effect of mitoK_ATP channel inhibition on the UM0112176-induced [Ca²⁺] increase in KLN205 and hNSCLC cells, respectively. h The reduction of UM0112176-induced calcium influx after inhibition of NCX in KLN205 cells. i The effect of UM0112176 on HK2 (green) interactions with mitochondria (magenta) in KLN205 cancer cells and normal HL-1 cells. To better visualize changes in HK2 localization in KLN205 cells (the left side of panel i), the green channel (HK2) is presented separately from merged magenta (mitochondria) and blue (nuclei) channels. For HL-1 cells, white color indicates localization of green-stained HK2 and magenta-colored mitochondria. Bar = 20 µm