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. 2019 Sep 20;13:1007. doi: 10.3389/fnins.2019.01007

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Copyright © 2019 Ubina, Magallanes, Srivastava, Warden, Yee and Salvaterra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DEGs are potentially related to Alzheimer’s relevant pathways and functions. (Top) IPA pathway analysis of DEGs in the Aβ42 vs. H9 comparison identified “decreased memory” (z = –2.213) and “increased neuronal cell death” (z = 1.658) as the lowest and highest scoring functional pathways. Individual genes are shown as graphic symbols representing molecule type and color coded by FC values (red = UP, green = DN). (Bottom) The most relevant IPA disease-related canonical pathway was “Neuroprotective role of THOP1 in Alzheimer’s disease” (p = 9.95E–03, overlap = 2 of 40 total genes in this pathway). The pathway genes were MME (aka NEP, neprilysin) an Aβ degrading metalloproteinase and SERPINA3 (aka ACT, alpha-1 antitrypsin) a protease inhibitor found in AD plaques (Top, circled in blue). MME is not directly included in the IPA “decreased memory” function but could potentially be related through its relationship to GRP.