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. 2019 Sep 26;9:13936. doi: 10.1038/s41598-019-50319-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MMV688345 does not affect ubiquinone biosynthesis. (a) Giemsa-stained thin smears of MMV688345-treated and control parasites. After 20 h of treatment, P. falciparum cultures were recovered for metabolomics analysis and a sample of each condition was maintained in culture to complete 48 h of treatment. (b) PCA model score plot of LC-HRMS data from analyzed P. falciparum samples comparing MMV688345-treated (Pf-T) and untreated control (Pf-UC) samples. (c) Levels of ubiquinone-9 detected in P. falciparum by LC-HRMS were not affected by MMV688345 treatment. (d) Effect of MMV688345 treatment on the mitochondrial membrane potential was assessed using MitoTracker^® after 20 and 48 h of treatment. Scale bar indicates 1 μm. Values represent means ± s.e.m. of at least three independent assays.