Table 2.

Semen Quality

Patients	TDF	TAF	P Value
Sperm concentration, x106 per mL	33.6 (1.1–144.1)	31.9 (7.1–82.9)	.152
Progressive motility, rapid progression + slow progression, %	8.3 (1.8–58.1)	23.3 (2.2–53.6)	.019
Vitality, live spermatozoa, %	61.5 (13–81)	66 (48–85)	.230
Sperm morphology, normal forms, %	5 (2–16)	3 (2.5–6)	.049

Lower reference limits (fifth percentiles and 95% confidence intervals) for semen characteristics [19] are: sperm concentration (x106 per mL), 15 (12–16); progressive motility (%), 32 (31–34); vitality (live spermatozoa, %), 58 (55–63); and sperm morphology (normal forms, %), 4 (3–4).

Abbreviations: TAF, tenofovir alafenamide; TDF, tenofovir disoproxil fumarate.