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. 2019 Sep 19;12:227. doi: 10.3389/fnmol.2019.00227

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Copyright © 2019 König, Dagenais, Senk, Djonov, Aegerter and Jaźwińska.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of Serotonin production by pcpa-treatment does not prevent HCS-cell regeneration. (A,B) Whole mount immunofluorescent staining for 5-HT and SV2 in pcpa-treated (B) and control (A) fins at 3 dpa. Pcpa treatment eliminates serotonin, but does not eliminate SV2 expression in HCS-cells. (A’,B’) The treatment does not prevent HCS-cell regeneration. (C,D) Whole mount immunofluorescence staining for Calretinin and SV2 in pcpa-treated (D) and control (C) fins at 3 dpa. Pcpa-treatment does not suppress the Calretinin expression in SV2-positive cells (C’,D’). (E) Density of 5-HT-positive cells in pcpa-treated fins decreased dramatically as compared to control fins, validating the activity of pcpa (72 ± 21 vs. 12 ± 10 cells per mm²). N ≥ 3. (F) Density of SV2-positive cells is similar in control and pcpa-treated fins (106 ± 26 vs. 92 ± 47 cell per mm²). N ≥ 3. (G) Density of Calretinin-positive cells remains unaltered despite of inhibition of serotonin production by the pcpa-treatment (126 ± 12 vs. 107 ± 44 cells per mm²). N ≥ 3.