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. 2019 Sep 20;7:200. doi: 10.3389/fcell.2019.00200

FIGURE 3.

FIGURE 3

WGCNA modules. (A) Pearson’s correlation values of WGCNA modules with the pathogenicity profile. (B,C) Correlation of the “pink” (B) or “black” (C) WGNCA module eigengene with the pathogenicity profile. Module eigengenes are the principle component of the expression levels of modules that contains similarly behaving genes, and therefore represent the expression patterns across all genes in a module. Each bar represents the expression of the module’s genes in an individual mouse infected with a particular strain of influenza at a certain dose for a set number of days (1, 2, 4, or 7). Color intensity represents strains/mutants with increasing pathogenicity, as in Figure 2. Dashed lines indicate dose separations for a single strain. Orange trace shows the pathogenicity profile.