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. 2019 Sep 20;7:200. doi: 10.3389/fcell.2019.00200

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Copyright © 2019 Mitchell, Eisfeld, Stratton, Heller, Bramer, Wen, McDermott, Gralinski, Sims, Le, Baric, Kawaoka and Waters.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overlap in biological measures and graph topology for SARS-CoV infection. Significance matrices were generated for SARS-CoV infection experiments as in Figure 4; however, weight loss values at each infection condition were used as a pathogenicity measurement. Weight loss correlations for early (days 1 and 2) and late (days 4 and 7) were combined to obtain the pathogenicity ranking.