Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effects of FDA-approved NMDAR channel blockers on wild-type and mutant GluN1/GluN2D receptors. Composite concentration-response curves of FDA-approved NMDAR antagonists were evaluated by TEVC recordings from Xenopus oocytes in the presence of 100 μM glutamate and 100 μM glycine at holding potential of −40 mV. (A) memantine, (B) dextromethorphan, (C) dextrorphan, and (D) ketamine. Data are mean ± SEM. Smooth curves are Equation 2 fitted to the data.
