FIG 2.

Virus titers and hematology of guinea pigs inoculated with LASV LF2384. When guinea pigs were euthanized (EU) or dead, organ and blood samples were collected, if available. (A) Homogenates of organs or whole-blood samples were used to titrate virus by plaque assay. The broken line indicates the detection limit (<2.0 log₁₀ PFU/g for organs, <2.0 log₁₀ PFU/ml for blood). Each symbol represents the value for an individual guinea pig. The means ± standard errors (error bars) for the guinea pig organs are shown. (B to D) Blood samples were collected from guinea pigs inoculated with LASV LF2384, and hematological parameters were measured. The numbers of white blood cells (WBC) (B), lymphocytes (LYM) (C), and platelets (PLT) (D) are shown. The broken lines indicate the lower limit of the normal range. Each symbol represents the value for an individual guinea pig. The means ± standard errors for the groups are shown. Statistical analyses were performed using Kruskal-Wallis test following Dunn’s multiple-comparison test (*, P < 0.01).