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Feedback relief following PI3K inhibition leads to Akt Ser473 accumulation. (A) Immunoblot showing time‐dependent re‐accumulation of phosphorylated Akt (Ser473) following PI3K inhibition by BYL719 (5 µm). (B) Immunoblot with indicated antibodies following transfection of HNSCC cells with myc‐tagged RICTOR. (C) Proliferation after 72 h of HNSCC cell lines at baseline compared to following transfection of myc‐tagged RICTOR upon increasing doses of BYL719 (0–40 µm). *P < 0.05.
