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. 2019 Sep 5;13(10):2033–2048. doi: 10.1002/1878-0261.12567

Figure 1.

Figure 1

Domain organization of HECT‐type E3 enzymes. The HECT E3s have been assigned to three subgroups according to their N‐terminal protein–protein interaction domains. The C2‐WW‐HECT members are composed of an N‐terminal protein kinase C‐related C2 domain, two‐four central WW domains for substrate recruitment and a C‐terminal HECT domain. HERC E3s have one (small HERC) or more RLDs (large HERC) that precede the HECT domain. Large HERCs contain additional domains, such as SPRY and WD40 domains. The SI(ngle)‐HECT subfamily is characterized by the presence of a HECT domain but lack both WW and RDL domains. These enzymes recruit the substrates through several distinct structural modules including armadillo repeat‐containing domain, amino‐terminal Zn‐finger of Ube3a ligase domain, WWE, BH3 domain, ankyrin repeat‐containing domain, polyadenylate‐binding protein C‐terminal domain, UBA, and zinc finger domain.