Fig. 6.

Time course of changes in total behavior in three representative animals that received either intrastriatal AAO or saline or intrastriatal AAO followed by amphetamine (AMP) as indicated in the legend. The first and second arrows indicate the onset and offset, respectively, of the bilateral infusion sequence. The asteriskbelow the second arrow indicates the time of the AMP injection. Note that, whereas behavior remains stable after vehicle infusion, AAO causes a near-total suppression of behavior that begins shortly after infusion offset. AMP reverses the AAO effect and elicits almost continuous behavioral activation.