Fig. 7.

A, Effects of AD-R ligands on hippocampal basal serotonin release. The ordinate indicates the mean ± SD (n = 6) of extracellular serotonin level (fmol/10 μl), and the abscissa shows the time in minutes. The open barindicates perfusion with 10 μm adenosine (AD), caffeine (CF),CPT, PD125944, DMPX, or 0.1 μmCCPA. The mean values obtained before and during perfusion with AD-R ligands were compared using repeated-measure one-way ANOVA and Dunnett's multiple comparison test.B, Concentration-dependent effects of AD-R ligands on the hippocampal basal serotonin release. The ordinate indicates the mean ± SD (n = 6) of percentage of control of the AUC value of extracellular serotonin level, and the abscissa shows the concentration of agents (log μm). The mean values obtained by control and during perfusion with AD-R ligands were compared using one-way ANOVA and Tukey's multiple comparison test (*p < 0.05, **p < 0.01).C, Effects of AD-R ligands, under the condition of A1-R blockade by 10 μm CPT, on the hippocampal basal serotonin release. The ordinate indicates the mean ± SD (n = 6) of extracellular serotonin level (fmol/10 μl), and the abscissa shows the time in minutes. The open barindicates perfusion with 10 μm CPT, and thestriped column indicates perfusion with 10 μmAD, CF,PD125944, or DMPX. The mean values obtained before and during perfusion with AD-R ligands were compared using repeated-measure one-way ANOVA and Dunnett's multiple comparison test. D, Concentration-dependent effects of AD-R ligands, under the condition of A1-R blockade by 10 μmCPT, on the hippocampal basal serotonin release. The ordinate indicates the mean ± SD (n = 6) of percentage of control of AUC of extracellular serotonin level, and the abscissa shows the concentration of agents (log μm). The mean values obtained by control and during perfusion with AD-R ligands were compared using one-way ANOVA and Tukey's multiple comparison test (*p < 0.05, **p < 0.01).