Fig. 7.

Swim maze performance in the saline-injected control mice and immunotoxin-injected mice. A, Time to reach the hidden platform on training trials was measured over three blocks in a 1 d swim maze task (spatial swim time). Control mice performed significantly better than lesioned mice on all three blocks of trials. B, Saporin-lesioned mice were also impaired in learning to swim to a visible platform, as measured by time to reach the visible platform on four training trials (cued swim time). However, the main effect on swim time on spatial training trials remained when swim time on cued trials was partialled out as a covariate.C, Correlation between proximity to platform on the spatial probe trial and hippocampal ChAT depletion. Better spatial performance was correlated significantly with higher hippocampal ChAT activity.