Table 1.
14 d WT | 30 d WT | 120 d WT | 120 d Nude | |
---|---|---|---|---|
MT-c17.2 grafts (β-Gal-positive) | 3 /3 (100%) | 3 /8 (37.5%) | 0 /8 (0%) | 3 /3 (100%) |
GDNF-c17.2 grafts (GDNF-positive) | 4 /4 (100%) | 5 /12 (41.6%) | 1 /8 (12.5%) | 3 /3 (100%) |
Animals showing β-Gal- or GDNF-immunoreactive cells in the striatum at the indicated time points were considered as positive. In general, most of the animals showed either a large engraftment (see Figs. 3, 4) or absence of positive cells. The engraftment efficiency of MT-c17.2 or GDNF-c17.2 cells was 100% in nude CD-1 mice (Nude) but declined over time in wild-type mice (WT).