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. 2001 Oct 15;21(20):7901–7908. doi: 10.1523/JNEUROSCI.21-20-07901.2001

Fig. 7.

Fig. 7.

GABAA receptor currents are comparable in ORAs and VRAs. A1–A3 andB1–B3 are recordings from an ORA and a VRA, respectively, at holding potential of −70 mV. In A1 andB1, a 0.5 sec 1 mm GABA pulse induced robust inward currents in both cells with a similar desensitization time course. At the end of the GABA pulse, the initial peak current (AP) desensitized 47% inA1 and 40% in B1. A2 andB2 show the similar inhibition of GABA-induced currents by the selective GABAA antagonist bicuculline (10 μm). The GABA-induced currents were reduced by 52 and 64% in an ORA (A2) and a VRA (B2), respectively. A3 and B3 were the responses induced by the selective GABAA receptor agonist muscimol (50 μm). In A3 andB3, the muscimol-induced peak current amplitudes amounted to 61 and 64% of the GABA induced currents. All recordings inA and B represent the same respective cells.