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Fibrosarcoma tumors secrete increased levels of ET on PID 9, 10, and 11. Extracellular fluid from fibrosarcoma tumor sites was sampled by microperfusion on PID 8–13 and compared with microperfusates from the hindlimb of naive mice. The relative level of ET was determined by flow cytometry. Group size is four to six mice per time point; ∗ indicates p < 0.05 compared with naive; # indicates p < 0.01 compared with naive.
