Skip to main content
. 2001 Dec 1;21(23):9235–9245. doi: 10.1523/JNEUROSCI.21-23-09235.2001

Fig. 2.

Fig. 2.

Effect of sHN and its derivatives on neurotoxicity by anti-APP antibody. Primary neurons were treated with 2.5 μg/ml 22C11 (anti-APP monoclonal antibody) in the presence or absence of sHN (10 nm,L; 10 μm, H), sHNG (10 nm,L; 10 μm,H), or 10 μm(H) sHNA. A, Cell mortality was measured by trypan blue exclusion assay 72 hr after the onset of 22C11 treatment. B, Cell damage was monitored before or after 22C11 treatment (at 24, 48, and 72 hr) by measuring released LDH in the culture medium. C, Phase-contrast microscopic views 72 hr after 22C11 treatment with or without sHN or HN derivatives. Representative views are indicated. Similar experiments were performed at least three times. ** and * indicate significant and not significant versus 22C11 treatment, respectively.