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. 2001 Dec 1;21(23):9345–9354. doi: 10.1523/JNEUROSCI.21-23-09345.2001

Fig. 7.

Fig. 7.

Effect of the specific EGF tyrosine kinase receptor inhibitor PD153035 on axonal regeneration after RIP nerve crush in saline without L-EGF supplementation. A, Frequency of preparations in which RPeD1 and VD2/VD3 were retrograde labeled by backfilling the RIP nerve after 2 d in culture in saline (saline only) or saline plus 100 nmPD153035 (saline + PD153035). Significantly fewer preparations with labeled RPeD1 or VD2/VD3 were observed in the presence of the kinase inhibitor. B, Frequency distribution of labeled RPA somata per CNS in preparations that were cultured for 2 d in saline plus 100 nm L-EGF (saline only) or saline plus 100 nm PD153035 (saline + PD153035) (bin width = 2). Compared with controls, treatment with PD153035 caused a significant reduction in number of labeled RPA somata.