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. 2001 Dec 1;21(23):9246–9254. doi: 10.1523/JNEUROSCI.21-23-09246.2001

Fig. 6.

Fig. 6.

Caspase-1 and -3 are sequentially activated in the spinal cord of ALS transgenic rats. a, Caspase-1-like activity was measured as described and is reported as fluorescence emitted by the free AMC after cleavage of the caspase-1 substrate YVAD-AMC. b, DEVD-AMC cleavage was measured to determine caspase-3 activity in spinal cord lysates of the ALS rats and their littermate controls. Caspase-3 activity is expressed as fluorescence emitted from the free fluorogenic group AMC. Data are the mean ± SD for experiments assayed in duplicate. Asterisks(*p < 0.05; **p < 0.01) indicate significant differences with respect to the control groups.Squares and diamondsindicate data derived from H46R-4 and control rats, respectively. Ages are in months.