Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Progressive pathology in spinal cord of transgenic rats
| Age (days) | H46R-4 | G93A-39 | |||||
|---|---|---|---|---|---|---|---|
| 90 | 120 | 150 | 170 | 90 | 120 | 130 | |
| Reactive astrogliosis | (+) | (+) | (++) | (+++) | (+) | (++) | (+++) |
| Motor neuron loss | (−) | (+) | (++) | (+++) | (+) | (++) | (+++) |
| Ubiquitination | (−) | (+) | (++) | (+++) | (+) | (++) | (+++) |
| Hyaline inclusion | (−) | (−) | (+) | (++) | (−) | (+) | (+) |
| Vacuolation | (−) | (−) | (−) | (±) | (−) | (+) | (++) |
| Estimated motor neurons Control 16.4 ± 1.7 (6 months) | 16.9 ± 2.0 | 13.1 ± 2.1 | 9.7 ± 2.2 | 5.4 ± 1.3 | 13.3 ± 1.4 | 7.1 ± 1.9 | 4.3 ± 0.9 |
