Fig. 4.

CREB^αΔ mutant mice exhibit heightened cocaine-conditioned place preference. The left side of the graph shows that no initial preference for either side exists for any of the experimental groups. The right side of the graph shows that CREB^αΔmutant mice show a preference to the side paired with 5 mg/kg cocaine, whereas their wild-type littermates do not show a preference for the side paired with the same dose of cocaine. However, at a dose of 10 mg/kg cocaine, both wild-type and mutant mice show significant preference for the cocaine-paired side. *p < 0.05 from saline group (n = 6 per group).