Table 1. Baseline Characteristics of the Study Population.
| Baseline Characteristic | No./Total No. (%) | P Value | |
|---|---|---|---|
| Mechanical Thrombectomy (n = 138) | Best Medical Management (n = 113) | ||
| Age, mean (SD), y | 65.2 (16.6) | 64.8 (12.8) | .85 |
| Female | 65/138 (47.1) | 51/113 (45.1) | .76 |
| Hypertension | 103/138 (74.6) | 80/113 (70.7) | .50 |
| Diabetes mellitus | 39/135 (28.9) | 29/112 (25.9) | .60 |
| Hyperlipidemia | 66/138 (47.8) | 54/113 (47.8) | >.99 |
| Atrial fibrillation | 40/136 (29.4) | 24/113 (21.2) | .14 |
| Coronary artery disease | 23/138 (17.4) | 30/113 (27.4) | .06 |
| Congestive heart failure | 14/121 (11.5) | 15/113 (13.2) | .69 |
| End-stage renal disease | 7/126 (5.5) | 2/111 (1.8) | .13 |
| Current smoking | 36/138 (26.1) | 45/112 (40.1) | .02 |
| Admission, mean (SD) | |||
| Glucose level, mg/dL | 126.7 (44.8) | 136.5 (64.0) | .16 |
| SBP, mm Hg | 147.9 (22.5) | 147.8 (31.0) | .99 |
| DBP, mm Hg | 83.3 (14.4) | 82.7 (20.3) | .81 |
| Pretreatment, % | |||
| Antiplatelet | 50.7 | 39.8 | .34 |
| Anticoagulant | 18.1 | 13.4 | .58 |
| NIHSS admission, median (IQR) | 4 (3-5) | 3 (2-4) | <.001 |
| ASPECTS admission, median (IQR) | 10 (9-10) | 9 (8-10) | .67 |
| Good collaterals on CTAa | 80/99 (81.8) | 49/61 (80.3) | .81 |
| Disability prior stroke, % | 22.9 | 27.0 | .49 |
| IVtPA | 74/137 (54.0) | 47/113 (41.5) | .05 |
| Onset to tPA, median (IQR), min | 120 (85-165) | 120 (90-180) | .97 |
| Onset-to-groin puncture time, median (IQR), min | 219 (165-397) | NA | NA |
| Groin puncture-to-reperfusion time, median (IQR), min | 44 (31-67) | NA | NA |
| Drip and ship | 30/138 (21.7) | 26/113 (23.0) | .81 |
| ICA | |||
| Extracranial | 10/138 (7.2) | 20/113 (17.7) | NA |
| Intracranial | 13/138 (9.4) | 9/113 (7.9) | NA |
| M1 MCA | 81/138 (58.7) | 40/113 (35.4) | NA |
| M2 MCA | 35/138 (25.4) | 45/113 (39.8) | NA |
| Occlusion | |||
| Proximalb | 104/138 (75.3) | 68/113 (60.2) | .01 |
| Tandem | 5/138 (3.6) | 1/113 (0.9) | .16 |
Abbreviations: ASPECTS, Alberta Stroke Program Early CT Score; CS, collateral score; CTA, computed tomography angiography; DBP, diastolic blood pressure; ELVO, emergency large-vessel occlusion; ICA, internal carotid artery; IQR, interquartile range; IVtPA, intravenous tissue plasminogen activator; MCA, middle cerebral artery; NA, not applicable; NIHSS, National Institutes of Health Stroke Scale; SBP, systolic blood pressure; tPA, tissue plasminogen activator.
SI conversion factor: To convert glucose to millimoles per liter, multiply by 0.0555.
Collateral score for anterior circulation ELVO was reported in a dichotomized fashion (ie, poor [CS = 0 or 1] vs good [CS = 2, 3, and 4]) using American Society of Interventional and Therapeutic Neuroradiology methods that have been shown to predict outcomes.20
Internal carotid artery, M1 middle cerebral artery.