Table 5. Overview of Primary and Secondary Analyses Evaluating the Association of Treatment Modality (Mechanical Thrombectomy vs Best Medical Management) With Safety and Efficacy Outcomes in the Systematic Review and Meta-analysis.
| Outcome | Type of Analysis | Unadjusted Analyses | Adjusted Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Studies | OR (95% CI) | P Value | Heterogeneity | No. of Studies | OR (95% CI) | P Value | Heterogeneity | ||||
| I2, % | P Value for Cochran Q | I2, % | P Value for Cochran Q | ||||||||
| 3-mo FFO | Without LOCF | 4 | 0.96 (0.71-1.30) | .78 | 0 | .48 | 3 | 1.13 (0.78-1.65) | .51 | 0 | .51 |
| With LOCF | 4 | 0.93 (0.69-1.26) | .65 | 0 | .40 | 3 | 1.09 (0.76-1.57) | .65 | 0 | .39 | |
| 3-mo FI | Without LOCF | 4 | 0.94 (0.48-1.86) | .86 | 71 | .02 | 3 | 1.11 (0.55-2.27) | .77 | 62 | .07 |
| With LOCF | 4 | 0.88 (0.41-1.87) | .74 | 76 | .005 | 3 | 0.96 (0.38-2.46) | .94 | 77 | .01 | |
| 3-mo Mortality | Without LOCF | 4 | 1.71 (0.52-5.61) | .38 | 62 | .05 | 2 | 1.28 (0.51-3.23) | .60 | 0 | .38 |
| With LOCF | 4 | 1.85 (0.54-6.28) | .32 | 64 | .04 | 2 | 1.45 (0.52-4.07) | .48 | 20 | .26 | |
| sICH | NA | 4 | 5.52 (1.91-15.94) | .002 | 0 | .83 | 2 | 2.89 (0.75-11.20) | .12 | 0 | .53 |
| Asymptomatic ICH | NA | 2 | 1.85 (0.34-10.13) | .48 | 84 | .01 | 1 | NA | NA | NA | NA |
Abbreviations: FFO, favorable functional outcome; FI, functional independence; ICH, intracranial hemorrhage; LOCF, last observation carried forward; NA, not applicable; OR, odds ratio; sICH, symptomatic intracranial hemorrhage.