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. 2019 Sep 23;76(12):1439–1445. doi: 10.1001/jamaneurol.2019.3063

Table 2. Univariable Analysis of DWI-Positive Imaging.

DWI Positive (Single or Multiple Lesions) Risk Factor, No./Total No. (%) RR (95% CI)
Present Absent
Medical history
Age >60 y 103/612 (16.8) 36/416 (8.7) 1.94 (1.36-2.78)
Female sex 52/522 (10.0) 87/506 (17.2) 0.58 (0.42-0.80)
Hypertension 68/480 (14.2) 71/548 (13.0) 1.09 (0.80-1.49)
Type 1 or 2 diabetes 25/140 (17.9) 114/888 (12.8) 1.39 (0.94-2.06)
Current smoker 17/105 (16.2) 122/923 (13.2) 1.25 (0.77-1.95)
Ischemic heart disease 11/87 (12.6) 128/941 (13.6) 0.93 (0.52-1.65)
Atrial fibrillation 6/51 (11.8) 133/977 (13.6) 0.86 (0.40-1.86)
Hyperlipidemia 46/342 (13.5) 93/686 (13.6) 0.99 (0.71-1.38)
Taking aspirin prior to event 48/347 (13.8) 91/681 (13.4) 1.04 (0.75-1.43)
Taking statin prior to event 35/285 (12.3) 104/743 (14.0) 0.88 (0.61-1.25)
Taking antihypertensive medication prior to event 59/419 (14.1) 80/609 (13.1) 1.07 (0.78-1.47)
No known vascular risk factors 48/352 (13.6) 91/676 (13.5) 1.01 (0.73-1.40)
Any history of migraine 25/256 (9.8) 114/772 (14.8) 0.66 (0.44-0.995)
History of migraine with aura 10/80 (12.5) 129/948 (13.6) 0.92 (0.50-1.68)
Any self-reported stress 14/158 (8.9) 125/870 (14.4) 0.62 (0.36-1.04)
Any motor or speech symptoms 39/218 (17.9) 100/810 (12.3) 1.45 (1.03-2.03)
Isolated sensory symptoms 61/482 (12.7) 78/546 (14.3) 0.89 (0.65-1.21)
Symptom duration <5 min 19/122 (15.6) 120/906 (13.2) 1.18 (0.75-1.84)
Progression of first to last symptoms >10 min 21/179 (11.7) 118/849 (13.9) 0.84 (0.55-1.30)
Ongoing symptoms at time of assessment 72/370 (19.5) 67/658 (10.2) 1.91 (1.41-2.60)
Previous identical event 20/238 (8.4) 119/790 (15.1) 0.56 (0.36-0.88)
Initial neurologic examination results normal 79/740 (10.7) 60/288 (20.8) 0.51 (0.38-0.70)

Abbreviations: DWI, diffusion-weighted imaging; RR, relative risk.