Figure 1.

Food consumption in female and male rats. Food consumption was measured prior to animal handling at approximately 08:00 h one day after administration of OLZ, SAM or the combination (day 2) to day 14. (a) An acute transient decrease in food consumption was noted for 3–4 days following SAM administration female rats (#p < 0.05). (b) Similarly, an acute decrease in food consumption was noted one day following SAM administration in male rats (#p < 0.05). In male rats only, a transient increase in food consumption was noted for two days following each OLZ injection (*p < 0.05). Importantly, these effects did not persist throughout the 14 day assessment. Data are expressed as mean ± SEM. Arrows indicate time of OLZ injection.

OLZ: olanzapine; SAM: samidorphan; VEH: vehicle