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. 2019 Jul 11;33(10):1303–1316. doi: 10.1177/0269881119856850

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Glucose clearance following bolus insulin in female rats. (a) OLZ significantly decreased glucose clearance following bolus insulin administration in female rats, which was normalized by co-administration of SAM (VEH + VEH vs. OLZ + VEH, *p < 0.05; OLZ + VEH vs. OLZ + SAM, #p< 0.05). (b) OLZ significantly decreased glucose clearance following bolus insulin administration in male rats (VEH + VEH vs. OLZ + VEH, *p < 0.05), which was partially but not significantly restored by co-administration of SAM (p = NS). Arrows indicate time of insulin injection (0.375 U/kg). Data are expressed as mean ± SEM.

OLZ: olanzapine; SAM: samidorphan; VEH: vehicle