Figure 7.

Rolling average of food consumption in non-human primates. A three-day rolling average of the qualitative food consumption for each treatment group was recorded. VEH-treated monkeys consumed the most food, likely due to the highly palatable high-fat diet. However, OLZ-treated monkeys did not eat as much compared with VEH-treated controls. Important to note is that this group gained more weight than the VEH-treated controls, suggesting a metabolic component associated with OLZ-induced weight gain. Food consumption was lowest in monkeys co-administered SAM. Furthermore, on day 35, monkeys that began receiving SAM ate less, but this effect was transient and food consumption returned to pre-change values approximately 12 days later. Data are expressed as mean ± SEM.

OLZ: olanzapine; SAM: samidorphan; VEH: vehicle