Volume of fat accretion in non-human primates. (a) All monkeys were
scanned prior to study start and again on day 28. In addition,
monkeys on OLZ alone that were transitioned to begin receiving SAM
on day 35 were scanned again on day 57. Scans were targeted to
assess abdominal adipose accretion and subcutaneous adipose
accretion. As indicated in the top panel, monkeys administered OLZ
alone gained appreciably more abdominal adipose accretion compared
with monkeys treated with OLZ and SAM. Furthermore, when the OLZ
alone group was switched to receive SAM, the rate of accretion was
considerably lower compared with that of the first 28 days (bottom
panel). Data are expressed as mean ± SEM. (b) Top: representative
scans at the level of the lower pole of the kidney (abdominal
adipose accretion) from an OLZ alone treated monkey taken on day 28
compared with its baseline scan. Bottom: A representative scan from
an OLZ and SAM treated monkey taken on day 28 and compared with its
baseline scan. The differences in adipose accretion are readily
visible between the two treatment groups.
OLZ: olanzapine; SAM: samidorphan; VEH: vehicle