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. 2019 Jul 11;33(10):1303–1316. doi: 10.1177/0269881119856850

Figure 8.

Figure 8.

Volume of fat accretion in non-human primates. (a) All monkeys were scanned prior to study start and again on day 28. In addition, monkeys on OLZ alone that were transitioned to begin receiving SAM on day 35 were scanned again on day 57. Scans were targeted to assess abdominal adipose accretion and subcutaneous adipose accretion. As indicated in the top panel, monkeys administered OLZ alone gained appreciably more abdominal adipose accretion compared with monkeys treated with OLZ and SAM. Furthermore, when the OLZ alone group was switched to receive SAM, the rate of accretion was considerably lower compared with that of the first 28 days (bottom panel). Data are expressed as mean ± SEM. (b) Top: representative scans at the level of the lower pole of the kidney (abdominal adipose accretion) from an OLZ alone treated monkey taken on day 28 compared with its baseline scan. Bottom: A representative scan from an OLZ and SAM treated monkey taken on day 28 and compared with its baseline scan. The differences in adipose accretion are readily visible between the two treatment groups.

OLZ: olanzapine; SAM: samidorphan; VEH: vehicle