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. 2019 Jul 11;33(10):1303–1316. doi: 10.1177/0269881119856850

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 9. — Glucose tolerance test and insulin concentrations in non-human primates. A decrease in insulin sensitivity (purple lines) in VEH-treated monkeys exposed to high-fat diet was noted on day 58 (c) but not day 28 (b). OLZ treatment produced a more rapid decrease in insulin sensitivity (purple lines) as compared with baseline (a) and VEH-treated monkeys on day 28 (d). However, when this group was measured again after having been switched to receive SAM, this response was no longer observed (e). Co-administration of OLZ with SAM maintained insulin sensitivity throughout the study (f and g).

NHP: non-human primate; OLZ: olanzapine; SAM: samidorphan; VEH: vehicle