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Opening the nanomedicine black box. Pictorial representation of the journey of a nanoparticle from the injection site to the target tissue (cancer). Several barriers have to be overcome in blood (protein corona, immune system), tissues (extravasation, matrix diffusion), and cells (membrane targeting, cell uptake, endosomal escape, and cell trafficking). Super-resolution imaging can shed light on the mechanisms of these phenomena, contributing to opening the black box of nanomedicine.
