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. 2019 Aug 5;13(9):9927–9935. doi: 10.1021/acsnano.9b04251

Scheme 1. Assembly of Megadalton DNA Origami Structures Is Driven by Peptide–Oligonucleotide Conjugates through Formation of Peptide Coiled-Coil Heterodimers and Pairing of Oligonucleotide Tags with Complementary ssDNA Handles.

Scheme 1

Peptide–oligonucleotide conjugates are formed via a Cu-free cycloaddition between the highlighted azide side chains of the peptides and the ring-strained dibenzylcyclooctyne groups of the oligonucleotide tags.