Figure 3.

Routes to modulate hepatic neutrophil recruitment, activation, and migration. The presence of neutrophils has been shown to be beneficial i.e., in sepsis where they are mobilized by recombinant CSF3 (Filgrastim). Similar effects are exerted by CXCR4/CXCL12 inhibitors such as AMD3100 and NOX-A12. Nanomedicines have been employed to deliver artificial micro-RNA inhibitor targeting miR223. Key molecules which regulate the activation of neutrophils include those pathways which lead to NET and ROS generation. The migration of neutrophils into inflamed tissue sites can be inhibited by targeting their adherence to the endothelium, i.e., by selectins such as L-selectin or integrins, i.e., ICAM1. The induction of a compound or mediator is indicated by a green triangle, and inhibition by a red cross.