Figure 2.

This figure summarizes the different neutrophil-based therapeutic strategies with various mechanisms of action described in bone marrow, blood and tumor. In green: prevention of neutrophil exit from bone marrow and entry to tumor tissue. In gray: depletion of neutrophils. In red: inhibition of the T-cell suppressive functions of neutrophils. In blue: prevention of neutrophil capacity to foster tumor cell proliferation and migration. In purple: promotion of the anti-tumor functions of neutrophils.