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. 2019 Sep 27;17:324. doi: 10.1186/s12967-019-2068-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Identification of top hypermethylated and hypomethylated mRNAs and lncRNAs in LUAD. a A flow diagram of the exploration of methylation-driven mRNA and lncRNA in LUAD. b–e The methylation degree when comparing cancer patients to normal patients in LUAD. The red curve indicates the methylation degree from the cancer group, the green curve indicates the methylation degree from the normal group, and the black line above the figure is the distribution of methylation levels in normal patients. f–i The correlation between methylation and gene expression in methylation-driven mRNAs and lncRNAs