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. 2019 Sep 27;17:324. doi: 10.1186/s12967-019-2068-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Functional enrichment analysis of methylation-driven mRNAs in LUAD. a The outer circle represents the expression (logFC) of methylation-driven mRNAs in each enriched GO (gene ontology) term: red dots on each GO term indicate upregulated methylation-driven mRNAs and blue dots indicate downregulated methylation-driven mRNAs. The inner circle indicates the significance of GO terms (log10-adjusted P values). b The circle indicates the correlation between the top 30 methylation-driven mRNAs and their gene ontology terms. c The distribution of the methylation-driven mRNAs in significant GO terms