Table 1.

Methylation-driven mRNAs

mRNA	Normal mean	Tumor mean	logFC	P Value	Adjusted-P	Cor	Cor P-value
ECSCR	0.651549745	0.777875207	0.255663395	6.97E−21	1.03E−18	− 0.401694346	1.85E−19
TBX4	0.3491894	0.503087408	0.526799315	7.58E−21	1.12E−18	− 0.353891186	3.64E−15
TIE1	0.559830867	0.675047137	0.269997212	1.21E−20	1.79E−18	− 0.406629901	6.08E−20
NEFH	0.254444122	0.435542374	0.775464224	1.40E−20	2.07E−18	− 0.321798888	1.16E−12
ACVRL1	0.398975345	0.517535129	0.375357195	3.26E−20	4.82E−18	− 0.386877674	4.73E−18
USHBP1	0.419199887	0.525059456	0.324842471	3.63E−20	5.37E−18	− 0.323007247	9.42E−13
ERN2	0.264647925	0.387648278	0.550673914	3.92E−20	5.80E−18	− 0.450728621	1.20E−24
COX7A1	0.560388444	0.666059579	0.249224026	9.41E−20	1.39E−17	− 0.342569242	3.00E−14
SULT1C4	0.176980042	0.3113128	0.814778224	2.45E−19	3.62E−17	− 0.375338318	5.28E−17
ART4	0.531234199	0.652680788	0.297029548	2.53E−19	3.75E−17	− 0.425340294	7.44E−22
HIST1H3E	0.313889479	0.456138176	0.539214244	1.45E−18	2.15E−16	− 0.390470196	2.19E−18
ZNF492	0.077650427	0.196364234	1.33846642	1.18E−17	1.75E−15	− 0.378866342	2.55E−17
ZNF728	0.138731042	0.290955121	1.068506001	1.32E−17	1.95E−15	− 0.346356662	1.50E−14
S1PR1	0.33644215	0.424456445	0.33525806	4.34E−17	6.43E−15	− 0.375495078	5.11E−17
MUC13	0.657841786	0.551979674	− 0.253125507	4.44E−17	6.57E−15	− 0.402604202	1.51E−19
CCDC8	0.360671572	0.480500959	0.413853596	8.99E−17	1.33E−14	− 0.389064482	2.96E−18
ZNF578	0.281145557	0.394615614	0.489130794	1.12E−16	1.66E−14	− 0.459621578	1.11E−25
FES	0.424918825	0.49946057	0.233183531	2.74E−16	4.05E−14	− 0.370960412	1.29E−16
ASCL1	0.096716299	0.200703748	1.053236604	2.98E−16	4.41E−14	− 0.331763879	2.08E−13
ALG1L	0.461379719	0.287062126	− 0.684591589	3.14E−16	4.65E−14	− 0.466908378	1.49E−26
ELF3	0.462412193	0.359973363	− 0.361289285	4.47E−16	6.61E−14	− 0.45067724	1.22E−24
TMEM88	0.583625618	0.738189625	0.338948249	7.89E−16	1.17E−13	− 0.390308898	2.27E−18
GSTM5	0.356896303	0.481942079	0.433354815	1.13E−15	1.68E−13	− 0.353462769	3.95E−15
IRX1	0.098629887	0.220552417	1.161024783	1.21E−15	1.79E−13	− 0.344157687	2.24E−14
ZNF454	0.183616121	0.338501411	0.88246912	1.44E−15	2.13E−13	− 0.602235321	3.13E−47
TK2	0.615291641	0.702921916	0.192094042	1.71E−15	2.52E−13	− 0.365352213	3.94E−16
ZSCAN1	0.289768404	0.400355348	0.466380783	2.83E−15	4.19E−13	− 0.397488998	4.73E−19
ZNF677	0.220497196	0.315626597	0.517458471	2.86E−15	4.23E−13	− 0.527352048	1.21E−34
ZNF582	0.130372053	0.239679107	0.878469505	5.74E−15	8.49E−13	− 0.558968642	1.43E−39
DAPP1	0.510432574	0.394016678	− 0.373463704	1.29E−14	1.91E−12	− 0.490584559	1.57E−29
SRPX2	0.600591335	0.480798168	− 0.32095226	1.42E−14	2.10E−12	− 0.383430149	9.83E−18
CCDC181	0.283605585	0.41823899	0.560441617	3.23E−14	4.78E−12	− 0.319044754	1.84E−12
SULT4A1	0.24652482	0.348099193	0.497765567	7.69E−14	1.14E−11	− 0.358208198	1.59E−15
LRRC4	0.321370351	0.418618502	0.38139924	1.26E−13	1.87E−11	− 0.421045183	2.10E−21
ZSCAN23	0.12251013	0.209336095	0.772920046	1.57E−13	2.32E−11	− 0.362584137	6.80E−16
F2RL1	0.242790645	0.208656331	− 0.218584138	1.74E−13	2.57E−11	− 0.35941342	1.26E−15
ZNF334	0.17466699	0.256829933	0.556206371	2.31E−13	3.43E−11	− 0.459451082	1.16E−25
ZNF471	0.130738051	0.279080546	1.094002465	5.46E−13	8.07E−11	− 0.548011494	8.37E−38
HOXB2	0.34354942	0.513088034	0.578688733	6.70E−13	9.91E−11	− 0.491155695	1.32E−29
PRR19	0.666407262	0.728756031	0.129031796	9.23E−13	1.37E−10	− 0.420836129	2.20E−21
AGR2	0.669953934	0.554274136	− 0.273462209	1.68E−12	2.49E−10	− 0.51205684	1.93E−32
NQO1	0.702158099	0.525979398	− 0.416789616	2.08E−12	3.08E−10	− 0.425444078	7.26E−22
GIPC2	0.179310415	0.281572165	0.651045433	3.52E−12	5.21E−10	− 0.36721046	2.73E−16
OXT	0.553265288	0.656785573	0.247451026	4.61E−12	6.83E−10	− 0.519344744	1.77E−33
B3GALT2	0.534256964	0.658626901	0.301927631	6.78E−12	1.00E−09	− 0.477778193	6.83E−28
EFS	0.197613625	0.297157242	0.588544115	1.42E−11	2.10E−09	− 0.391422631	1.78E−18
RAB34	0.295528869	0.254270265	− 0.21693631	2.05E−11	3.03E−09	− 0.424411453	9.32E−22
ACTRT3	0.391186063	0.353188058	− 0.147418408	5.54E−11	8.21E−09	− 0.329154572	3.27E−13
CLDN8	0.727830255	0.618464903	− 0.234910297	9.70E−11	1.44E−08	− 0.328690081	3.55E−13
AQP1	0.366569984	0.501482299	0.452110121	2.34E−10	3.46E−08	− 0.597245937	2.74E−46
SP8	0.202841356	0.297916967	0.554558466	2.69E−10	3.98E−08	− 0.317009628	2.58E−12
HORMAD2	0.350476203	0.461146819	0.395909658	3.14E−10	4.65E−08	− 0.457907737	1.76E−25
GALM	0.255948625	0.226747119	− 0.174770041	6.86E−10	1.02E−07	− 0.356239606	2.33E−15
RABGGTB	0.47835678	0.385164319	− 0.312612985	6.89E−10	1.02E−07	− 0.3330019	1.67E−13
KCNE3	0.256671142	0.314316199	0.292295525	7.52E−10	1.11E−07	− 0.350037722	7.53E−15
ZNF879	0.147629821	0.2000367	0.438280535	1.01E−09	1.50E−07	− 0.453856587	5.23E−25
ZNF257	0.157589016	0.245609973	0.640202155	1.28E−09	1.89E−07	− 0.359120932	1.34E−15
ZNF382	0.101492	0.295488981	1.541738316	1.35E−09	1.99E−07	− 0.391566521	1.73E−18
GSTM1	0.156396431	0.253910031	0.699109797	2.76E−09	4.08E−07	− 0.563212162	2.84E−40
PLAU	0.62150196	0.702145935	0.176011973	4.00E−09	5.92E−07	− 0.570934425	1.41E−41
PIGR	0.667952501	0.708575582	0.085176236	5.52E−09	8.16E−07	− 0.658618149	3.68E−59
CFTR	0.282943087	0.394972666	0.481240926	9.95E−09	1.47E−06	− 0.42150843	1.88E−21
SPDYC	0.704147468	0.724837107	0.041779213	1.76E−08	2.60E−06	− 0.47588325	1.18E−27
ZNF418	0.242511045	0.347906619	0.520649675	2.19E−08	3.23E−06	− 0.60435923	1.23E−47
KLHDC9	0.218223326	0.21602453	− 0.014610182	2.63E−08	3.90E−06	− 0.324984031	6.72E−13
ZNF69	0.117564379	0.142619404	0.278719274	2.66E−08	3.94E−06	− 0.321104504	1.30E−12
FAM84A	0.212175332	0.283041565	0.415757	3.53E−08	5.23E−06	− 0.335916441	9.96E−14
PPP1R14D	0.554947827	0.482097369	− 0.203027589	6.64E−08	9.82E−06	− 0.560710402	7.40E−40
TCP11	0.624104627	0.659912943	0.080487807	7.18E−08	1.06E−05	− 0.651746879	1.43E−57
ZNF300	0.328409005	0.415250076	0.338486746	9.38E−08	1.39E−05	− 0.472110183	3.46E−27
MPV17L	0.092385716	0.163253978	0.821376431	1.86E−07	2.75E−05	− 0.441792534	1.23E−23
KRT20	0.790374237	0.804070021	0.02478522	2.92E−07	4.33E−05	− 0.571800235	1.00E−41
GKN2	0.599299248	0.671212935	0.163493955	4.56E−07	6.76E−05	− 0.340697654	4.22E−14
ZNF502	0.329208879	0.402697069	0.290691725	6.68E−07	9.88E−05	− 0.663271171	2.91E−60
C17orf98	0.545496557	0.602566194	0.143549644	1.03E−06	0.000151843	− 0.529865333	5.12E−35
ZNF880	0.140875018	0.238786926	0.76130805	1.04E−06	0.000154315	− 0.560715099	7.38E−40
ZNF701	0.240700225	0.290476188	0.271182411	1.55E−06	0.000229592	− 0.408643207	3.83E−20
NR0B1	0.283614274	0.392651776	0.469320279	1.59E−06	0.000235507	− 0.320709703	1.39E−12
ZNF43	0.067179039	0.115788942	0.78541442	1.79E−06	0.000265629	− 0.375124186	5.52E−17
HCAR1	0.43400231	0.376162376	− 0.206347167	1.93E−06	0.000285658	− 0.401199574	2.07E−19
IRX2	0.289887257	0.40281496	0.474625351	3.59E−06	0.000530859	− 0.539421825	1.83E−36
TMEM63A	0.188744901	0.177446694	− 0.089051973	4.10E−06	0.000607535	− 0.345096982	1.89E−14
ITPRIPL1	0.294502802	0.374069204	0.345023839	4.14E−06	0.000613146	− 0.44960488	1.61E−24
LYZ	0.699231698	0.733682794	0.069385864	4.77E−06	0.000705417	− 0.424840466	8.40E−22
IFNLR1	0.246226199	0.232227751	− 0.084443891	9.60E−06	0.001421224	− 0.420673159	2.29E−21
TUSC1	0.13659181	0.18296341	0.421684184	9.60E−06	0.001421229	− 0.395587597	7.19E−19
MAGEB2	0.842482835	0.77366049	− 0.122946694	1.08E−05	0.001598591	− 0.352008819	5.20E−15
BVES	0.191406638	0.252664551	0.400582407	1.12E−05	0.001655808	− 0.321449081	1.23E−12
LRRIQ4	0.704379076	0.645150221	− 0.126716926	1.21E−05	0.001791741	− 0.38912631	2.93E−18
RASSF10	0.120420032	0.181039038	0.588225416	5.00E−05	0.007400364	− 0.328252794	3.83E−13
PRICKLE4	0.605330662	0.686379771	0.181283603	8.15E−05	0.012068682	− 0.318883347	1.89E−12
SYCP2	0.665037997	0.675303689	0.022099668	0.000123074	0.018214969	− 0.655943521	1.55E−58
WBP2NL	0.524579367	0.489275744	− 0.1005133	0.000184004	0.027232614	− 0.343246032	2.65E−14
BST2	0.422881206	0.380549863	− 0.152166944	0.000187292	0.027719241	− 0.589617095	7.07E−45
PLSCR4	0.17571366	0.196664014	0.162506649	0.000241916	0.035803514	− 0.365149084	4.10E−16
GBP4	0.149941894	0.137445221	− 0.125546784	0.000249246	0.036888372	− 0.316476516	2.82E−12
RPL7A	0.801995847	0.754500966	− 0.088072019	0.000275207	0.040730644	− 0.319271372	1.77E−12
ARHGDIB	0.327607353	0.313354218	− 0.064173323	0.000282085	0.04174863	− 0.552243	1.77E−38
CYB5A	0.127300153	0.141309476	0.150624055	0.000302943	0.044835593	− 0.371106098	1.25E−16